stem cell factor การใช้

• Kit ( CD117 ) is the receptor of Stem Cell Factor.
• Analysts said the stem cell factor is a product with moderate sales potential.
• Jun transcriptionally activates the promoters of SCF ( stem cell factor ) and CCL5.
• It is adjacent to stromal cells that secrete ligands, such as stem cell factor ( SCF ).
• However, Erwin said his company hopes to manufacture the stem cell factor soon using tobacco plants in Owensboro.
• Ligands that bind to RTKs include fibroblast growth factors, epidermal growth factors, platelet-derived growth factors, and stem cell factor.
• In mouse ESCs, Sall4 was found to bind the essential stem cell factor, octamer-binding transcription factor 4 ( PTEN ).
• Amgen said it planned to file for marketing approval with the FDA for stem cell factor within the next few months.
• Testing was conducted on 205 patients with breast cancer, and results showed the stem cell factor was helpful in chemotherapy treatment programs.
• Figure 1 : Alternative splicing of the same RNA transcript produces soluble and transmembrane forms of stem cell factor ( SCF ).
• Like the two drugs that have made Amgen a multibillion-dollar company, Epogen and Neupogen, stem cell factor prompts the production of blood cells.
• Many markers belong to the cluster of differentiation series, like : CD34, CD38, CD90, CD133, CD105, CD45, and also c-kit,-the receptor for stem cell factor.
• CFU-e cells express Epo receptor, c-Kit ( Stem cell factor receptor ), transferrin receptor ( CD71 + ), and are Ter119 ( glycophorin-A associated antigen )-negative.
• Although it was overshadowed by the news about the Lou Gehrig's disease drug, Amgen's other new drug candidate, stem cell factor, is a much larger potential product.
• Briefly, eCSCs have been first identified through the expression of c-kit, the receptor of the stem cell factor and the absence of common hematopoietic markers, like CD45.
• However, its absence in late spermatogonia permits c-kit expression, which is subsequently activated by its ligand SCF ( stem cell factor ) secreted by sertoli cells, resulting in further differentiation.
• On Friday, Amgen also reported positive results from Phase III trials of its stem cell factor, used in conjunction with Neupogen, and will file within a few months for regulatory approval of the procedure.
• The two drugs, stem cell factor and granulocyte colony stimulating factor, stimulated the bone marrow to produce numerous stem cells, which entered the bloodstream, migrated to the damaged heart, and turned into new heart muscle.
• The company reported positive results in the final stage of clinical trials for stem cell factor, a possible $ 1 billion drug that would be used to increase blood cell production in cancer patients undergoing aggressive chemotherapy.
• CD117 is a receptor tyrosine kinase type III, which binds to stem cell factor ( a substance that causes certain types of cells to grow ), also known as " steel factor " or " c-kit ligand ".